Phenotypes for Otx1 Otx2 MGI:3845768 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Otx1^tm1Asim/Otx1^tm2(otd)Asim Otx2^tm1Pas/Otx2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx1^tm1Asim mutation (2 available); any Otx1 mutation (86 available)
Otx1^tm2(otd)Asim mutation (1 available); any Otx1 mutation (86 available)
Otx2^tm1Pas mutation (2 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:47899 )

• mice die at birth

nervous system

abnormal brain morphology ( J:47899 )

• mice exhibit abnormal brain morphology

• however, the dorsal thalamus, Ammon's horn, and pretectum absent in Otx1^tm1Asim/Otx1^tm1Asim Otx2^tm1Pas/Otx2⁺ are restored

abnormal midbrain morphology ( J:47899 )

• mice exhibit abnormal mesencephalic morphology with a reduction in thickness of the alar region compared to in wild-type mice

abnormal cerebellum morphology ( J:47899 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24