Phenotypes Associated with This Genotype

Genotype
MGI:3845765

• Allelic Composition: Otx1^tm2(otd)Asim/Otx1^tm2(otd)Asim
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:47899 )

• 5% of mice die prior to weaning compared to 30% of Otx1^tm1Asim homozygotes

nervous system

nervous system phenotype ( J:47899 )

N • telencephalic structural defects observed in Otx1^tm1Asim homozygotes are rescued

abnormal telencephalon development ( J:47899 )

• cell proliferation in the dorsal telencephalon is greater than in Otx1^tm1Asim homozygotes

abnormal cerebellar foliation ( J:47899 )

• in 65% of mice

decreased brain size ( J:47899 )

• 17% of mice exhibit reduced brain size compared with in wild-type mice

decreased brain weight ( J:47899 )

• 17% of mice exhibit a 10% reduction in brain weight compared with wild-type mice

abnormal midbrain morphology ( J:47899 )

• mesencephalic structural defects observed in Otx1^tm1Asim homozygotes are partially rescued

decreased inferior colliculus size ( J:47899 )

• 30% of mice exhibit a 15% reduction in colliculus size compared with wild-type mice

• 50% of mice exhibit an intermediate reduction in colliculus size compared with wild-type mice and Otx1^tm1Asim homozygotes

decreased superior colliculus size ( J:47899 )

• 30% of mice exhibit a 15% reduction in colliculus size compared with wild-type mice

• 50% of mice exhibit an intermediate reduction in colliculus size compared with wild-type mice and Otx1^tm1Asim homozygotes

vision/eye

abnormal eye morphology ( J:47899 )

• 80% of mice exhibit reduced cilliary process and thickened iris compared to in wild-type mice

absent lacrimal glands ( J:47899 )

• in two-thirds of mice

abnormal iris morphology ( J:47899 )

• 80% of mice exhibit thickened iris compared to in wild-type mice

hearing/vestibular/ear

absent lateral semicircular canal ( J:47899 )

behavior/neurological

behavior/neurological phenotype ( J:47899 )

N • unlike Otx1^tm1Asim homozygotes, mice exhibit moderate-speed turning behavior and lack seizures

endocrine/exocrine glands

absent lacrimal glands ( J:47899 )

• in two-thirds of mice

absent Harderian gland ( J:47899 )

• in two-thirds of mice