Phenotypes Associated with This Genotype

Genotype
MGI:3845666

• Allelic Composition: Igha^tm2Grh/Igha^tm2Grh
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal class switch recombination ( J:72521 )

• B cells cultured with LPS produce levels of IgA that are almost 10-fold higher than controls

• the IgA levels approach those seen when wild-type B cells are activated in the presence of LPS and TGF-beta

• surface IgA expression is also enhanced by LPS compared to controls

hematopoietic system

abnormal class switch recombination ( J:72521 )

• B cells cultured with LPS produce levels of IgA that are almost 10-fold higher than controls

• the IgA levels approach those seen when wild-type B cells are activated in the presence of LPS and TGF-beta

• surface IgA expression is also enhanced by LPS compared to controls