Phenotypes Associated with This Genotype

Genotype
MGI:3844995

• Allelic Composition: Mapt^{tm3(Hdac2)Jae}/Mapt^{tm3(Hdac2)Jae}
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired contextual conditioning behavior ( J:148391 )

• show markedly decreased freezing behaviour in both context-dependent and tone-dependent fear learning

• time spent in a freezing position is about half that of controls for the context-depending test and only about 1/10^th of controls for tone-dependent testing

abnormal spatial learning ( J:148391 )

• mice have increased escape latency throughout a 9 day training process in a Morris water maze

• mice do not show a preference for the target quadrant when the hidden platform is removed whereas the control mice spend significantly more time in the target quadrant

abnormal spatial working memory ( J:148391 )

• mice show impairment of spatial working memory in a T-maze non-matching-to-place task with a third less correct guesses than controls after 2 days of training

nervous system

abnormal hippocampus CA1 region morphology ( J:148391 )

• the number of presynaptic terminals of functional synapses is significantly decreased in the CA1 striatum radiatum

abnormal dentate gyrus morphology ( J:148391 )

• the density of dendritic spines along dentate gyrus granule cells is markedly decreased

abnormal hippocampus pyramidal cell morphology ( J:148391 )

• the overall level of acetylated lysine on histones is decreased in these neurons compared to controls

• the density of dendritic spines along individual dendrites of hippocampal CA1 pyramidal neurons is markedly decreased

reduced long-term potentiation ( J:148391 )

• LTP induced by two trains of high frequency stimulation in CA1 neurons is impaired