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Phenotypes Associated with This Genotype
Genotype
MGI:3844928
Allelic
Composition		 Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+
Olig3tm1(cre)Ynka/Olig3+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Smo/EYFP)Amc mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
Olig3tm1(cre)Ynka mutation (0 available); any Olig3 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:147427 )
• partial; some pups survive postnatally

nervous system
nervous system phenotype ( J:147427 )
N
• brains are morphologically indistinguishable from controls
abnormal thalamus morphology ( J:147427 )
• expansion of the expression domain of the orphan receptor ROR alpha indicates that the the ventral posterior nucleus (VP) is increased in size
• in E18.5 brains, molecular marker analysis indicates that the entire postmitotic thalamus exhibits rostroventral identity
abnormal lateral geniculate nucleus morphology ( J:147427 )
• based on thalamic labeling by cholera toxin B subunit injection, the volume of the dorsal lateral geniculate nucleus (dLG) is increased more than 3-fold compared to control neonatal animals; expansion of the expression domain of the orphan receptor ROR alpha indicates that the dLG is increased in size

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory