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Phenotypes Associated with This Genotype
Genotype
MGI:3844817
Allelic
Composition		 Dcxtm1Caw/Y
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcxtm1Caw mutation (0 available); any Dcx mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Dyslaminated interneuron populations in Dcxtm1Caw/Y Dclk2tm1.2Jgg/Dclk2tm1.2Jgg and Dcxtm1Caw/Y mice

nervous system
abnormal hippocampus CA3 region morphology ( J:148345 )
• the CA3 region is dyslaminated by 11 days of age
abnormal hippocampal mossy fiber infrapyramidal bundle morphology ( J:148345 )
• the infrapyramidal mossy fiber bundle crosses the pyramidal layer and merges prematurely with the suprapyrimidal bundle
abnormal inhibitory postsynaptic currents ( J:148345 )
• the frequency of spontaneous sIPSC among pyramidal neurons is somewhat reduced compared to controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/08/2026
MGI 6.24 		The Jackson Laboratory