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Phenotypes Associated with This Genotype
Genotype
MGI:3844551
Allelic
Composition
Tg(CAG-PKD2)#Hwl/?
Genetic
Background
involves: FVB/NJ
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No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype

Cystic kidneys in Tg(CAG-PKD2)#Hwl/? mice

renal/urinary system
• dilated (J:148377)
• dilated (J:148377)
• increase in the number of proliferating cells per tubule, located around cysts especially at late cyst stages (J:148377)
• increase in the number of apoptotic cells per tubule mainly at the intermediate stage of cyst formation (J:148377)
• increase in the number of proliferating cells per tubule, located around cysts especially at late cyst stages (J:148377)
• increase in the number of apoptotic cells per tubule mainly at the intermediate stage of cyst formation (J:148377)
• bilateral cysts first appearing at 6 months of age (J:148377)
• number and size of cysts increases with age (J:148377)
• cysts develop mostly from proximal tubules but cysts developing form collecting ducts and distal tubules are also seen (J:148377)
• cysts display distinct morphological stages characterized by changes in the morphology of cells lining the cysts from cuboidal to flat (J:148377)
• bilateral cysts first appearing at 6 months of age (J:148377)
• number and size of cysts increases with age (J:148377)
• cysts develop mostly from proximal tubules but cysts developing form collecting ducts and distal tubules are also seen (J:148377)
• cysts display distinct morphological stages characterized by changes in the morphology of cells lining the cysts from cuboidal to flat (J:148377)

Mouse Models of Human Disease
OMIM ID Ref(s)
Polycystic Kidney Disease 2; PKD2 613095 J:148377


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory