Mouse Genome Informatics
cn
    Ptentm1Hwu/Ptentm1Hwu
Trp53tm1Brn/Trp53tm1Brn

involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• all mice treated with an adenovirus expressing cre die by 6 months of age

tumorigenesis
• urinary bladder tumors in Adeno-cre treated mice are of epithelial origins and exhibit features of carcinoma in situ and high-grade invasive carcinoma with areas of transitional cell, squamous, and sarcomatoid carcinoma
• by 6 months, all mice treated with an adenovirus expressing cre (Adeno-cre) develop large urinary bladder tumors unlike wild-type mice
• by 4 to 6 months, 60% of Adeno-cre treated mice exhibit metastasis in the local lymph nodes, spleen, liver, and diaphragm
• however, treatment of mice with rapamycin following Adeno-cre injection prevents urinary bladder tumor formation

Mouse Models of Human Disease
OMIM IDRef(s)
Bladder Cancer 109800 J:146760