About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3844304
Allelic
Composition		 Stat4tm1Jni/Stat4tm1Jni
Stat6tm1Jni/Stat6tm1Jni
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat4tm1Jni mutation (0 available); any Stat4 mutation (65 available)
Stat6tm1Jni mutation (0 available); any Stat6 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased interferon-gamma secretion ( J:96338 )
• restimulation of lymphocytes from Ova-immunized mice leads to enhanced IFN-gamma secretion
decreased interleukin-4 secretion ( J:96338 )
• restimulation of lymphocytes from Ova-immunized mice fails to solicit an IL-4 response
increased susceptibility to autoimmune diabetes ( J:96338 )
• mice have a median diabetes-free survival of 7 days after low dose streptozotocin injection compared to 9 days for wild-type controls
• blood glucose levels are significantly higher than controls throughout the entire observation time compared to wild-type littermates

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory