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Phenotypes Associated with This Genotype
Genotype
MGI:3844300
Allelic
Composition
Ank1RBC2/Ank1RBC2
Genetic
Background
involves: 129S1/Sv * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ank1RBC2 mutation (0 available); any Ank1 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• the number of live births is less than expected (J:148127)
• the number of live births is less than expected (J:148127)
• fewer than expected mice are present at weaning (J:148127)
• fewer than expected mice are present at weaning (J:148127)
• all mice die by 8 weeks of age (J:148127)
• all mice die by 8 weeks of age (J:148127)

hematopoietic system
• severe (J:148127)
• severe (J:148127)
• as early as E18.5, mice exhibit red cell fragmentation and membrane blebbing unlike in wild-type mice (J:148127)
• as early as E18.5, mice exhibit red cell fragmentation and membrane blebbing unlike in wild-type mice (J:148127)
• as early as E18.5 (J:148127)
• as early as E18.5 (J:148127)
• as early as E18.5 (J:148127)
• as early as E18.5 (J:148127)
• mice exhibit circulating nucleated erythroblasts unlike in wild-type mice (J:148127)
• mice exhibit circulating nucleated erythroblasts unlike in wild-type mice (J:148127)
• as early as E18.5 (J:148127)
• as early as E18.5 (J:148127)
• 6-fold (J:148127)
• 6-fold (J:148127)
• erythrocyte half-life is 2 days compared to 32 days in wild-type mice (J:148127)
• mice exhibit an increase in the markers of red cell destruction (bilirubin serum levels and iron overload in the liver) compared to in wild-type mice (J:148127)
• erythrocyte half-life is 2 days compared to 32 days in wild-type mice (J:148127)
• mice exhibit an increase in the markers of red cell destruction (bilirubin serum levels and iron overload in the liver) compared to in wild-type mice (J:148127)
• increased (J:148127)
• increased (J:148127)

homeostasis/metabolism
• 4 times higher than in wild-type mice (J:148127)
• 4 times higher than in wild-type mice (J:148127)
• 4-fold higher at 52 days (J:148127)
• 4-fold higher at 52 days (J:148127)

immune system
• 6-fold (J:148127)
• 6-fold (J:148127)

liver/biliary system
• 4-fold higher at 52 days (J:148127)
• 4-fold higher at 52 days (J:148127)
• in 15% of mice within hours of birth (J:148127)
• in 15% of mice within hours of birth (J:148127)

Mouse Models of Human Disease
OMIM ID Ref(s)
Spherocytosis, Type 1; SPH1 182900 J:148127


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory