Mouse Genome Informatics
involves: 129S1/Sv * BALB/c
phenotype observed in females
phenotype observed in males
N normal phenotype
• the number of live births is less than expected
• fewer than expected mice are present at weaning
• all mice die by 8 weeks of age

hematopoietic system
• severe
• as early as E18.5, mice exhibit red cell fragmentation and membrane blebbing unlike in wild-type mice
• as early as E18.5
• as early as E18.5
• mice exhibit circulating nucleated erythroblasts unlike in wild-type mice
• as early as E18.5
• 6-fold
• erythrocyte half-life is 2 days compared to 32 days in wild-type mice
• mice exhibit an increase in the markers of red cell destruction (bilirubin serum levels and iron overload in the liver) compared to in wild-type mice

• 4 times higher than in wild-type mice
• 4-fold higher at 52 days

immune system
• 6-fold

liver/biliary system
• 4-fold higher at 52 days
• in 15% of mice within hours of birth

Mouse Models of Human Disease
Spherocytosis, Type 1; SPH1 182900 J:148127