Analysis Tools
immune system
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• positive but not negative selection is impaired as evidenced by the low number of anti-HY (male antigen) T cells found in female mice
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• there is about a 2-fold drop peripheral CD4 T cells for female but not male mice compared to controls
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• there is a decrease (greater than 2-fold) in CD4-single positive thymocytes that express the transgenic TCR in female mice
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• there is about a 2-fold drop in lymph node cellularity for female but not male mice compared to controls
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hematopoietic system
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• positive but not negative selection is impaired as evidenced by the low number of anti-HY (male antigen) T cells found in female mice
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• there is about a 2-fold drop peripheral CD4 T cells for female but not male mice compared to controls
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• there is a decrease (greater than 2-fold) in CD4-single positive thymocytes that express the transgenic TCR in female mice
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