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Phenotypes Associated with This Genotype
Genotype
MGI:3843819
Allelic
Composition		 Il6sttm1Thir/Il6sttm1Thir
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic
Background		 involves: 129 * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6sttm1Thir mutation (1 available); any Il6st mutation (84 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal negative T cell selection ( J:133059 )
• the number of CD8lo single-positive thymocytes bearing transgenic TCR are several fold higher than in controls indicating a defect in negative selection

hematopoietic system
abnormal negative T cell selection ( J:133059 )
• the number of CD8lo single-positive thymocytes bearing transgenic TCR are several fold higher than in controls indicating a defect in negative selection

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory