Analysis Tools
behavior/neurological
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• mice show a flexed posture when inverted, similar to Erbb2 conditional mutants
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• mice exhibit a wide-based, ataxic gait, similar to Erbb2 conditional mutants; onset of abnormalities is delayed and is less pronounced, however, relative to Erbb2 conditional animals
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nervous system
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• functional specificity of connections between afferents and motor neurons is preserved in conditional mutants
• anatomical specificity of connections between muscle afferents projecting to agonistic and antagonistic motor neurons is preserved in conditional mutants
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• at P5, ventral root potentials are normal, but by P14, amplitudes of potentials are reduced by >80% compared to controls
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