Phenotypes Associated with This Genotype

Genotype
MGI:3843778

• Allelic Composition: Il6st^tm1Thir/Il6st^tm1Thir
• Genetic Background: B6.Cg-Il6st^tm1Thir

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal osteoblast physiology ( J:144906 )

• osteoblasts reduce their proliferation and their alkaline phosphatase activity by a greater amount than controls when cultured with IL-6 family cytokines

• proliferation reduction caused by IL-6/sIL-6R, IL-11, and LIF were 43%, 36%, and 13% compared to 32%, 20%, and 10% in controls

• osteoblast activity is increased 2.8- and 2.0- fold compared to controls when cultured with IL-6/sIL-6R or IL-11

abnormal bone structure ( J:144906 )

• skeleton area is 5% higher than in controls

increased bone mineral content ( J:144906 )

• bone mineral content is 16% higher than in controls

increased bone mineral density ( J:144906 )

• bone mineral density is 11% greater in these mice than in controls

increased trabecular bone thickness ( J:144906 )

• trabecular number and total bone volume of the tibia is increased by a third

• trabecular thickness is also increased and trabecular separation is decreased

increased bone mineralization ( J:144906 )

• mineral apposition rate is augmented in these mice

increased bone ossification ( J:144906 )

• bone formation rate is augmented in these mice

cellular

abnormal osteoblast physiology ( J:144906 )

• osteoblasts reduce their proliferation and their alkaline phosphatase activity by a greater amount than controls when cultured with IL-6 family cytokines

• proliferation reduction caused by IL-6/sIL-6R, IL-11, and LIF were 43%, 36%, and 13% compared to 32%, 20%, and 10% in controls

• osteoblast activity is increased 2.8- and 2.0- fold compared to controls when cultured with IL-6/sIL-6R or IL-11