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Phenotypes Associated with This Genotype
Genotype
MGI:3843660
Allelic
Composition
Il6sttm1Thir/Il6sttm1Thir
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6sttm1Thir mutation (1 available); any Il6st mutation (84 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• there is almost a 3-fold increase in the number of cells contained in the peritoneal exudate of 5-month old mice
• size of spleen increases with age with mean cellularity being over 2-fold higher than controls by 5 months of age

immune system
• size of spleen increases with age with mean cellularity being over 2-fold higher than controls by 5 months of age
• the number of CD45R+ B cells is increased in in the enlarged lymph node organs
• the number of CD4-positive T cells increases by 1.3 to 2.7 fold in in the enlarged lymph node organs
• the number of CD8-positive T cells increases by 1.3 to 2.7 fold in the enlarged lymph node organs
• B cells stimulated with anti-CD40 produce more immunoglobulins than controls
• addition of IL-6 to stimulation enhances even more the production of immunoglobulins
• production of antigen-specific IgG2a is increased in these mice after immunization with T cell dependent antigen
• production of antigen-specific IgG2b is increased in these mice after immunization with T cell dependent antigen
• by 5 months of age
• by 5 months of age, enlargement occurs to cervical, axillar, inguinal, and mesenteric lymph nodes
• by 5 months of age
• by 5 months of age
• by 5 months of age
• bone marrow derived dendritic cells treated with IL-6 have a greater reduction in MHC-II surface expression than in controls
• dendritic cells isolated from lymph nodes have a 40% reduction in surface expression of MHC-II
• activated T cells secrete 1.6-fold more IFN-gamma than controls
• CD4+ T cells produce less 0.6 fold-less IL-4 than controls when activated

hematopoietic system
• size of spleen increases with age with mean cellularity being over 2-fold higher than controls by 5 months of age
• the number of CD45R+ B cells is increased in in the enlarged lymph node organs
• the number of CD4-positive T cells increases by 1.3 to 2.7 fold in in the enlarged lymph node organs
• the number of CD8-positive T cells increases by 1.3 to 2.7 fold in the enlarged lymph node organs
• B cells stimulated with anti-CD40 produce more immunoglobulins than controls
• addition of IL-6 to stimulation enhances even more the production of immunoglobulins
• production of antigen-specific IgG2a is increased in these mice after immunization with T cell dependent antigen
• production of antigen-specific IgG2b is increased in these mice after immunization with T cell dependent antigen

nervous system
• the abnormal action potential of cardiomycoytes at 80% repolarization is not prolonged to the extent wild-type cardiomyocytes are when LIF is administered
• L-type Ca2+ current intensities in cardiomyocytes are not influenced by IL-6 or LIF incubation as wild-type cardiomyocytes are

cardiovascular system
• L-type Ca2+ current intensities in cardiomyocytes are not influenced by IL-6 or LIF incubation as wild-type cardiomyocytes are
• transient increases of intracellular calcium in cardiomyocytes are not influenced by IL-6 or LIF neither


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory