growth/size/body
• there is almost a 3-fold increase in the number of cells contained in the peritoneal exudate of 5-month old mice
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• size of spleen increases with age with mean cellularity being over 2-fold higher than controls by 5 months of age
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immune system
• size of spleen increases with age with mean cellularity being over 2-fold higher than controls by 5 months of age
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• the number of CD45R+ B cells is increased in in the enlarged lymph node organs
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• the number of CD4-positive T cells increases by 1.3 to 2.7 fold in in the enlarged lymph node organs
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• the number of CD8-positive T cells increases by 1.3 to 2.7 fold in the enlarged lymph node organs
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• B cells stimulated with anti-CD40 produce more immunoglobulins than controls
• addition of IL-6 to stimulation enhances even more the production of immunoglobulins
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• production of antigen-specific IgG2a is increased in these mice after immunization with T cell dependent antigen
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• production of antigen-specific IgG2b is increased in these mice after immunization with T cell dependent antigen
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• by 5 months of age
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• by 5 months of age, enlargement occurs to cervical, axillar, inguinal, and mesenteric lymph nodes
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• by 5 months of age
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• by 5 months of age
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• by 5 months of age
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• bone marrow derived dendritic cells treated with IL-6 have a greater reduction in MHC-II surface expression than in controls
• dendritic cells isolated from lymph nodes have a 40% reduction in surface expression of MHC-II
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• activated T cells secrete 1.6-fold more IFN-gamma than controls
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• CD4+ T cells produce less 0.6 fold-less IL-4 than controls when activated
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hematopoietic system
• size of spleen increases with age with mean cellularity being over 2-fold higher than controls by 5 months of age
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• the number of CD45R+ B cells is increased in in the enlarged lymph node organs
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• the number of CD4-positive T cells increases by 1.3 to 2.7 fold in in the enlarged lymph node organs
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• the number of CD8-positive T cells increases by 1.3 to 2.7 fold in the enlarged lymph node organs
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• B cells stimulated with anti-CD40 produce more immunoglobulins than controls
• addition of IL-6 to stimulation enhances even more the production of immunoglobulins
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• production of antigen-specific IgG2a is increased in these mice after immunization with T cell dependent antigen
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• production of antigen-specific IgG2b is increased in these mice after immunization with T cell dependent antigen
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nervous system
• the abnormal action potential of cardiomycoytes at 80% repolarization is not prolonged to the extent wild-type cardiomyocytes are when LIF is administered
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• L-type Ca2+ current intensities in cardiomyocytes are not influenced by IL-6 or LIF incubation as wild-type cardiomyocytes are
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cardiovascular system
• L-type Ca2+ current intensities in cardiomyocytes are not influenced by IL-6 or LIF incubation as wild-type cardiomyocytes are
• transient increases of intracellular calcium in cardiomyocytes are not influenced by IL-6 or LIF neither
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