Phenotypes for Hcst Tyrobp MGI:3843528 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Hcst^tm1.1Cln/Hcst^tm1.1Cln Tyrobp^tm1Lll/Tyrobp^tm1Lll
Genetic Background	B6.Cg-Hcst^tm1.1Cln Tyrobp^tm1Lll

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcst^tm1.1Cln mutation (0 available); any Hcst mutation (8 available)
Tyrobp^tm1Lll mutation (1 available); any Tyrobp mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal NK T cell physiology ( J:147867 )

• NK cells fail to kill m157-expressing target cells unlike wild-type cells

abnormal response to infection ( J:147867 )

• 4 days after infection with mouse cytomegalovirus, mice exhibit higher titers than in similarly treated Tyrobp^tm1Lll homozygotes

hematopoietic system

abnormal NK T cell physiology ( J:147867 )

• NK cells fail to kill m157-expressing target cells unlike wild-type cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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