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Phenotypes Associated with This Genotype
Genotype
MGI:3843267
Allelic
Composition		 Srftm2Nor/Srftm2Nor
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Srftm2Nor mutation (0 available); any Srf mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:124767 )
• overall reduction of CD19+ B cells in bone marrow
abnormal mature B cell morphology ( J:124767 )
• reduced surface expression of IgM in cells from the spleen, lymph nodes, bone marrow and blood
• surface expression of IgD is not affected
decreased B-1 B cell number ( J:124767 )
• CD19+ IgM+ CD5+ peritoneal B cells are decreased in number
absent marginal zone B cells ( J:124767 )
• in spite of normal follicular architecture

hematopoietic system
decreased B cell number ( J:124767 )
• overall reduction of CD19+ B cells in bone marrow
decreased B-1 B cell number ( J:124767 )
• CD19+ IgM+ CD5+ peritoneal B cells are decreased in number
absent marginal zone B cells ( J:124767 )
• in spite of normal follicular architecture
abnormal mature B cell morphology ( J:124767 )
• reduced surface expression of IgM in cells from the spleen, lymph nodes, bone marrow and blood
• surface expression of IgD is not affected

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory