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Phenotypes Associated with This Genotype
Genotype
MGI:3843175
Allelic
Composition
Cd19tm1(cre)Cgn/Cd19+
Ep300tm2Reck/Ep300+
Genetic
Background
involves: 129/Sv * 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Ep300tm2Reck mutation (0 available); any Ep300 mutation (98 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: mice have a longer life span than mice on a mixed background containing C57BL/6
• all mice die prematurely, but female mice exhibit a shorter life span than male mice (median survival of 73 weeks for females compared with over 90 weeks for males)

immune system
• Background Sensitivity: mice develop systemic lupus erythematosus symptoms later in life than when mice are on a mixed background containing C57BL/6


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/06/2026
MGI 6.24
The Jackson Laboratory