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Phenotypes Associated with This Genotype
Genotype
MGI:3843174
Allelic
Composition
Cd19tm1(cre)Cgn/Cd19+
Ep300tm2Reck/Ep300+
Genetic
Background
involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (6 available); any Cd19 mutation (18 available)
Ep300tm2Reck mutation (0 available); any Ep300 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all mice die by prematurely, but female mice exhibit a shorter life span than male mice (median survival of 29 weeks for females compared with 43 weeks for males)
• Background Sensitivity: mice have a shorter life span than mice on a mixed background containing C57BL/6

immune system
• mice exhibit paravascular cell infiltration and thickening of the artery walls unlike in wild-type mice
• mature B cells in aged mice lack CD23 expression unlike in wild-type mice indicating an age-dependent loss of part of the normal B cell differentiation program
• fewer transitional B cells with the AA4.1+ phenotype are detected compared to in wild-type mice
• however, the number of total transitional B cells is normal
• the number of activated B cells in the spleen is more than in wild-type mice
• at 4 to 6 months
• in some mice
• following ovalbumin immunization, the memory response upon boosting with ovalbumin is 3-fold less than in similarly treated wild-type mice
• following IgM stimulation, apoptosis of transitional B cells is greater than in wild-type mice
• however, mature B cells exhibit normal apoptosis rates
• in response to BCR engagement by anti-IgM, B cell proliferation is less than in wild-type mice
• however, B cells exhibit normal proliferation in response to LPS, IL4, anti-CD40 and ODN1668, and IgM proliferation can be restored by co-stimulation with anto-CD40 or IL4
• prior to ovalbumin immunization, mice exhibit 3-fold more ovalbumin-specific immunoglobins compared to in wild-type mice
• however, the humoral response 14 days after immunization is normal
• 1.6-fold at 10 months of age
• Background Sensitivity: mice develop systemic lupus erythematosus symptoms earlier in life than when mice are on a mixed background containing FVB/N
• interstitial

renal/urinary system
• interstitial
• glomeruli are enlarged and often filled with homogeneous protein deposits in the kidney, spleen, liver, and lungs unlike in wild-type mice

cardiovascular system
• mice exhibit paravascular cell infiltration and thickening of the artery walls unlike in wild-type mice

hematopoietic system
• following IgM stimulation, apoptosis of transitional B cells is greater than in wild-type mice
• however, mature B cells exhibit normal apoptosis rates
• mature B cells in aged mice lack CD23 expression unlike in wild-type mice indicating an age-dependent loss of part of the normal B cell differentiation program
• fewer transitional B cells with the AA4.1+ phenotype are detected compared to in wild-type mice
• however, the number of total transitional B cells is normal
• with islands of granulopoiesis
• 4- to 20-fold in the spleen
• the number of activated B cells in the spleen is more than in wild-type mice
• at 4 to 6 months
• in response to BCR engagement by anti-IgM, B cell proliferation is less than in wild-type mice
• however, B cells exhibit normal proliferation in response to LPS, IL4, anti-CD40 and ODN1668, and IgM proliferation can be restored by co-stimulation with anto-CD40 or IL4
• 1.6-fold at 10 months of age

cellular
• following IgM stimulation, apoptosis of transitional B cells is greater than in wild-type mice
• however, mature B cells exhibit normal apoptosis rates


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/07/2017
MGI 6.11
The Jackson Laboratory