Mouse Genome Informatics
hm
    Gnmttm1Ymac/Gnmttm1Ymac
involves: 129/Sv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
liver/biliary system
• at 17 months, mice develop fatty nodules in the liver unlike in wild-type mice (J:146081)
• 6 of 7 mice exhibit multiple gray-whitish nodules approximately 1 mm long unlike in wild-type mice (J:147857)
• male mice exhibit coagulative necrosis, sinusoidal dilatation, and congestion in the liver unlike wild-type mice (J:147857)
• 5 of 7 female mice exhibit degenerative changes and perinuclear vacuoles in the liver unlike wild-type mice (J:147857)
• at 9 months, livers exhibit degenerative changes and perinuclear vacuoles unlike in wild-type mice (J:147857)
• in male mice livers
• at 11 weeks
• at 4 weeks, 11 weeks, and 9 months, liver weights are increased compared to in wild-type mice
• however, 4 week old mice have normal liver weights
• coagulative necrosis in male mice livers
• degenerative changes are observed in the liver of 5 of 7 female mice
• at 9 months, livers exhibit degenerative changes and perinuclear vacuoles unlike in wild-type mice

homeostasis/metabolism
• serum methionine levels are 1.9- to 2.4-fold greater than in wild-type mice
• at 4 weeks, female mice exhibit increased alanine transaminase (ALT) serum levels compared to in wild-type mice (J:146081)
• at 11 weeks, male and female exhibit increased ALT serum levels compared to in wild-type mice (J:146081)
• at 4 weeks, female mice exhibit increased alanine transaminase (ALT) serum levels compared to in wild-type mice (J:147857)
• at 11 weeks, male and female exhibit increased ALT serum levels compared to in wild-type mice (J:147857)
• 3 of 7 male mice exhibit increased glycogen accumulation in the cytoplasm compared to in wild-type mice
• 5 of 7 female mice exhibit increased glycogen accumulation in the cytoplasm and sinusoids of the liver compared to in wild-type mice
• PAS staining revealed that two-thirds of mice exhibit increased accumulation of glycogen live levels compared to in wild-type mice

tumorigenesis
• in 43% of female mice
• 7 of 7 female mice develop hepatocellular carcinoma (HCC) with a mean age of 20.1 months that are multifocal and in different lobes
• 3 of 6 male mice develop HCC with a mean age of 21.6 months that are unifocal and mainly found in the left hepatic lobe
• at 17 months, mice develop fatty nodules in the liver unlike in wild-type mice
• the mean number of tumor nodules per mouse is 2.3 in male mice and 8 in female mice

immune system

hematopoietic system

cardiovascular system
• in male mice livers

Mouse Models of Human Disease
OMIM IDRef(s)
Glycine N-Methyltransferase Deficiency 606664 J:147857