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Phenotypes Associated with This Genotype
Genotype
MGI:3842654
Allelic
Composition		 Lattm1Les/Lattm1Les
Lcp2tm5(Lat/Lcp2)Gak/Lcp2tm5(Lat/Lcp2)Gak
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lattm1Les mutation (0 available); any Lat mutation (11 available)
Lcp2tm5(Lat/Lcp2)Gak mutation (0 available); any Lcp2 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased double-positive T cell number ( J:147721 )
• double-positive thymocytes are absent in these mice
arrested T cell differentiation ( J:147721 )
• thymocytes are arrested at the DN3 stage

hematopoietic system
decreased double-positive T cell number ( J:147721 )
• double-positive thymocytes are absent in these mice
arrested T cell differentiation ( J:147721 )
• thymocytes are arrested at the DN3 stage

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory