Phenotypes Associated with This Genotype

Genotype
MGI:3842653

• Allelic Composition: Lcp2^{tm5(Lat/Lcp2)Gak}/Lcp2^{tm5(Lat/Lcp2)Gak}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

thymus hypoplasia ( J:147721 )

• cellularity of the thymus is 40% of wild-type reflecting diminished double-positive and single-positive thymocyte populations

abnormal thymocyte activation ( J:147721 )

• calcium flux upon activation of double-positive thymocytes is severely diminished compared to controls

decreased double-positive T cell number ( J:147721 )

• number of double-positive thymocytes is reduced by about 40%

arrested T cell differentiation ( J:147721 )

• thymocytes are arrested at the double-positive stage

• the few single-positive CD8⁺ T cells present express heat-stable antigen and are considered an immature, transient population

decreased single-positive T cell number ( J:147721 )

• mature single positive thymocytes are absent

hematopoietic system

thymus hypoplasia ( J:147721 )

• cellularity of the thymus is 40% of wild-type reflecting diminished double-positive and single-positive thymocyte populations

abnormal thymocyte activation ( J:147721 )

• calcium flux upon activation of double-positive thymocytes is severely diminished compared to controls

decreased double-positive T cell number ( J:147721 )

• number of double-positive thymocytes is reduced by about 40%

arrested T cell differentiation ( J:147721 )

• thymocytes are arrested at the double-positive stage

• the few single-positive CD8⁺ T cells present express heat-stable antigen and are considered an immature, transient population

decreased single-positive T cell number ( J:147721 )

• mature single positive thymocytes are absent

endocrine/exocrine glands

thymus hypoplasia ( J:147721 )

• cellularity of the thymus is 40% of wild-type reflecting diminished double-positive and single-positive thymocyte populations

abnormal thymocyte activation ( J:147721 )

• calcium flux upon activation of double-positive thymocytes is severely diminished compared to controls