Phenotypes Associated with This Genotype

Genotype
MGI:3842633

• Allelic Composition: Btla^tm1Dgra/Btla^tm1Dgra; Tg(TcraTcrb)1100Mjb/?
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal peripheral T cell anergy ( J:147751 )

• CD8⁺ T cells from these mutant mice induce diabetes as early as 6 days after transfer into Tg(Ins2-TFRC/OVA)296Wehi transgenic mice that express OVA in insulin-producing cells

• 60% of transgenic mice develop diabetes and almost all mice have invasive insulitis compared to transgenic mice receiving wild-type OT-I cells where 60% of mice display no disease

• mutant OT-I T cells found in the pancreatic lymph nodes have twice as much proliferation as controls 50 hours after transfer compared to transferred wild-type OT-I T cells

• two weeks after transfer, there are twice as many mutant OT-I T cells in pancreatic lymph nodes compared to wild-type OT-I T cells controls

• thus, mutant autoreactive OT-I CD8⁺ T cells are resistant to tolerance induction mechanisms that limit the expansion of autoreactive CD8 ⁺ T cells