Analysis Tools
mortality/aging
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• at 9 to 12 months
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immune system
| N |
• despite immune system defects, B cell activation occurs normally
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• B cells are more prone to spontaneous apoptosis and exhibit increased apoptosis in response to anti-Fas or anti-IgM stimulation compared to similarly treated wild-type cells
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• 2-fold in the spleen and 7-fold in the lymph nodes
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• mild
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• mild
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• mild
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• levels of anti-DNA IgG1 are increased compared to in wild-type mice
• at 7 to 9 months, anti-nuclear antibodies are increased compared to in wild-type mice
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hematopoietic system
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• B cells are more prone to spontaneous apoptosis and exhibit increased apoptosis in response to anti-Fas or anti-IgM stimulation compared to similarly treated wild-type cells
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• Ter-119+ erythroid cells are increased 2-fold in the spleen compared to in wild-type mice
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• 2-fold in the spleen and 7-fold in the lymph nodes
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• mild
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• mild
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• mild
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cellular
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• B cells are more prone to spontaneous apoptosis and exhibit increased apoptosis in response to anti-Fas or anti-IgM stimulation compared to similarly treated wild-type cells
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growth/size/body
