Prkcd^tm1Qxu
Targeted Allele Detail

Summary

• Symbol: Prkcd^tm1Qxu
• Name: protein kinase C, delta; targeted mutation 1, Qingbo Xu
• MGI ID: MGI:2385756
• Synonyms: PCKdelta^-, PCKdelta KO
• Gene: Prkcd Location: Chr14:30317311-30348167 bp, - strand Genetic Position: Chr14, 18.82 cM
• Alliance: Prkcd^tm1Qxu page

Prkcd^tm1Qxu/Prkcd^tm1Qxu mice are protected from age-related hepatosteatosis

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78680
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The translation initiation codon was disrupted by insertion of a lacZ-neo cassette into the first coding exon of the gene via homologous recombination. Protein product was absent in homozygous mutant animals as determined by Western blot analysis of heart, lung, and liver tissues. (J:78680)

Expression

In Mice Carrying this Mutation:	85 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkcd Mutation: 52 strains or lines available

References

• Original: J:78680 Leitges M, et al., Exacerbated vein graft arteriosclerosis in protein kinase Cdelta-null mice. J Clin Invest. 2001 Nov;108(10):1505-12
• All: 34 reference(s)