Mouse Genome Informatics
ht
    Nr4a2tm1Tpe/Nr4a2+
B6.129P2-Nr4a2tm1Tpe
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• male mice exhibit a 59% dopamine decreased in the prefrontal cortex and a 38% dopamine decrease in the hippocampus compared to wild-type mice
• DOPAC levels are reduced 35% in the prefrontal cortex and 41% in the hippocampus in male mice compared to in wild-type mice
• HVA levels are reduced in the striatum in male mice compared to in wild-type mice
• female mice exhibit a 39% increase in DOPAC in the striatum and 12% in HVA compared to in wild-type mice
• male mice exhibit a 147% increase in dopamine turnover compared to in wild-type mice
• in female mice, dopamine turnover in increased in the striatum by 52% DOPAC/DA and 23% HVA/DA
• however, dopamine turnover in the prefrontal lobe in female mice is normal
• male mice exhibit a 28% increase in noradrenaline in striatum and an 11% increase in female mice in the hippocampus compared to in wild-type mice
• male mice exhibit a reduction in 5-HIAA in the striatum (-10%), hippocampus (-13%), and midbrain (-13%) with decreased 5-HT turnover in the striatum (-18%), hippocampus (-19%), and MB (-18%) compared to in wild-type mice
• female mice exhibit an increase in 5-HT in the midbrain (7%), 5-HIAA in the prefrontal cortex (11%), striatum (13%), and hippocampus (21%) with increased 5-HT turnover in striatum (20%), cerebellum (31%), and hippocampus (20%) compared to in wild-type mice

behavior/neurological
• phencyclidine-treated male mice exhibit an 86% increase in locomotion and a 78% increase in motility compared to similarly treated wild-type mice
• phencyclidine-treated female mice exhibit an 134% increase in locomotion and a 87% increase in motility compared to similarly treated wild-type mice
• phencyclidine-treated female mice are more active than similarly treated male mice
• however, mice exhibit normal suppression of hyperactivity when treated with haloperidol
• male mice treated with amphetamine exhibit a 68% increase in locomotion and 64% increase in motility compared to similarly treated wild-type mice
• female mice treated with amphetamine exhibit a 90% increase in locomotion and 60% increase in motility compared to similarly treated wild-type mice
• in a forced-swim test, mice exhibit increased immobility compared to wild-type mice
• male mice exhibit a 45% decrease in retention latency in a passive avoidance task compared to wild-type mice
• male mice are 82% more active and 65% more motile than wild-type mice
• female mice are 99% more active and 68% more motile than wild-type mice
• mice treated with amphetamine exhibit a 68% increase in locomotion and 64% increase in motility compared to similarly treated wild-type mice
• female mice treated with amphetamine exhibit a 90% increase in locomotion and 60% increase in motility compared to similarly treated wild-type mice
• phencyclidine-treated male mice exhibit an 86% increase in locomotion and a 78% increase in motility compared to similarly treated wild-type mice
• phencyclidine-treated female mice exhibit an 134% increase in locomotion and a 87% increase in motility compared to similarly treated wild-type mice
• phencyclidine-treated female mice are more active than similarly treated male mice
• however, mice exhibit normal suppression of hyperactivity when treated with haloperidol

nervous system
• male mice exhibit a 59% dopamine decreased in the prefrontal cortex and a 38% dopamine decrease in the hippocampus compared to wild-type mice
• DOPAC levels are reduced 35% in the prefrontal cortex and 41% in the hippocampus in male mice compared to in wild-type mice
• HVA levels are reduced in the striatum in male mice compared to in wild-type mice
• female mice exhibit a 39% increase in DOPAC in the striatum and 12% in HVA compared to in wild-type mice
• male mice exhibit a 147% increase in dopamine turnover compared to in wild-type mice
• in female mice, dopamine turnover in increased in the striatum by 52% DOPAC/DA and 23% HVA/DA
• however, dopamine turnover in the prefrontal lobe in female mice is normal

Mouse Models of Human Disease
OMIM IDRef(s)
Schizophrenia; SCZD 181500 J:147544