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Phenotypes Associated with This Genotype
Genotype
MGI:3841490
Allelic
Composition
Htr2ctm1Jke/Y
Tg(Pomc1-cre)16Lowl/0
Genetic
Background
B6.Cg-Htr2ctm1Jke Tg(Pomc1-cre)16Lowl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2ctm1Jke mutation (1 available); any Htr2c mutation (16 available)
Tg(Pomc1-cre)16Lowl mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice exhibit a decreased survival rate compared to wild-type mice
• mice fed a regular diet exhibit decreased survival compared to mice fed a high fat diet

nervous system

behavior/neurological
N
• mice exhibit normal food intake and locomotor activity levels

homeostasis/metabolism
N
• mice exhibit normal leptin levels and anorexigenic responses to d-Fen and metachlorophenylpiperazine

adipose tissue
N
• mice exhibit normal adiposity in response to a high fat diet

growth/size/body
N
• mice exhibit normal weight gain in response to a high fat diet


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/06/2026
MGI 6.24
The Jackson Laboratory