Phenotypes Associated with This Genotype

Genotype
MGI:3841456

• Allelic Composition: Ksr1^tm1Shaw/Ksr1^tm1Shaw; Tg(DO11.10)10Dlo/0
• Genetic Background: involves: BALB/c * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:75739 )

• decreased T cell proliferation when stimulated with ovalbumin peptide

abnormal CD4-positive T cell differentiation ( J:75739 )

• cultured T cells under conditions that promote either Th1 or Th2 differentiation fail to produce appreciable amounts of IFNG or IL4

• addition of supplemental IL2 allows for normal Th1 and Th2 differentiation

decreased interleukin-2 secretion ( J:75739 )

• at 24, 48, and 72 h after stimulation compared to controls

hematopoietic system

decreased T cell proliferation ( J:75739 )

• decreased T cell proliferation when stimulated with ovalbumin peptide

abnormal CD4-positive T cell differentiation ( J:75739 )

• cultured T cells under conditions that promote either Th1 or Th2 differentiation fail to produce appreciable amounts of IFNG or IL4

• addition of supplemental IL2 allows for normal Th1 and Th2 differentiation

cellular

decreased T cell proliferation ( J:75739 )

• decreased T cell proliferation when stimulated with ovalbumin peptide