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Phenotypes Associated with This Genotype
Genotype
MGI:3841417
Allelic
Composition		 Cd40tm1Geha/Cd40tm1Geha
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40tm1Geha mutation (0 available); any Cd40 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased spleen germinal center number ( J:82298 )
• germinal centers are infrequent in TNP-LPS immunized mutants
decreased spleen germinal center size ( J:82298 )
• germinal centers are smaller in TNP-LPS immunized mutants
abnormal lymph node germinal center morphology ( J:82298 )
• smaller and fewer germinal centers are observed in response to TI-I antigen, TNP-LPS

hematopoietic system
decreased spleen germinal center number ( J:82298 )
• germinal centers are infrequent in TNP-LPS immunized mutants
decreased spleen germinal center size ( J:82298 )
• germinal centers are smaller in TNP-LPS immunized mutants

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory