Analysis Tools
behavior/neurological
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• heterozygotes exhibit reduced exploratory activity in open field chambers relative to wild-type littermates, as measured by the total distance traveled and number of instances of rearing at the periphery within the first 5 min
• however, no differences are observed in the time spent at the periphery, suggesting absence of anxiety
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nervous system
| N |
• heterozygotes show normal peripheral nerve morphology, with no signs of myelination defects, axonal swelling, or fiber degeneration in the sciatic nerve
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• heterozygotes exhibit an intermediate phenotype with a PPI level lower than that of wild-type littermates
• however, no differences are observed in acoustic startle responses at different intensities, suggesting that hearing is normal
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