Phenotypes Associated with This Genotype

Genotype
MGI:3841109

• Allelic Composition: Nfkb2^tm2Brv/Nfkb2^tm2Brv; Tg(Tnfsf13b)1Fma/?
• Genetic Background: B6.Cg-Nfkb2^tm2Brv Tg(Tnfsf13b)1Fma

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:113556 )

N • there are no elevated levels of anti-dsDNA antibodies detected in circulation compared to transgenic mice on a wild-type background that have high levels of auto-antbodies

decreased marginal zone B cell number ( J:113556 )

• marginal zone B cells are almost completely absent in the spleen

absent spleen marginal zone ( J:113556 )

• marginal zones are absent in these mice

abnormal B cell activation ( J:113556 )

• B cells have a strong response to T cell independent antigens producing higher levels of antigen-specific IgM, IgG2a, IgG2b class antibodies than wild-type controls

• however, there is no significant elevation of antigen-specific IgG1, IgG3, and IgA antibodies as is observed in transgenic mice on a wild-type background

• levels of antibodies produced are also lower than those in transgenic mice on a wild-type background

homeostasis/metabolism

increased urine protein level ( J:113556 )

• about half of 8-month old mice have proteinuria in their urine at 30 mg/dl concentration

renal/urinary system

increased urine protein level ( J:113556 )

• about half of 8-month old mice have proteinuria in their urine at 30 mg/dl concentration

hematopoietic system

decreased marginal zone B cell number ( J:113556 )

• marginal zone B cells are almost completely absent in the spleen

absent spleen marginal zone ( J:113556 )

• marginal zones are absent in these mice

abnormal B cell activation ( J:113556 )

• B cells have a strong response to T cell independent antigens producing higher levels of antigen-specific IgM, IgG2a, IgG2b class antibodies than wild-type controls

• however, there is no significant elevation of antigen-specific IgG1, IgG3, and IgA antibodies as is observed in transgenic mice on a wild-type background

• levels of antibodies produced are also lower than those in transgenic mice on a wild-type background