Phenotypes Associated with This Genotype

Genotype
MGI:3841107

• Allelic Composition: Chuk^tm2Mka/Chuk^tm2Mka; Tg(Tnfsf13b)1Fma/?
• Genetic Background: B6.Cg-Chuk^tm2Mka Tg(Tnfsf13b)1Fma

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased transitional stage B cell number ( J:113556 )

• numbers of T2 B cells are slightly enlarged in the spleen

decreased marginal zone B cell number ( J:113556 )

• marginal zone B cell numbers are reduced compared to controls

absent spleen marginal zone ( J:113556 )

• marginal zones could not be localized in these mice

abnormal B cell activation ( J:113556 )

• B cells have a strong response to T cell independent antigens producing higher levels of antigen-specific IgM, IgG2a, IgG2b class antibodies than wild-type controls

• however, there is no significant elevation of antigen-specific IgG1, IgG3, and IgA antibodies as is observed in transgenic mice on a wild-type background

• levels of antibodies produced are also lower than those in transgenic mice on a wild-type background

increased anti-double stranded DNA antibody level ( J:113556 )

• anti-dsDNA antibodies of the IgM class are found in circulation

• titers of these auto-antibodies increase slightly with age

• no significantly elevated anti-dsDNA antibodies are found within the other immunoglobulin classes which differs from transgenic mice not homozygote for the Chuk^tm2Mka allele

homeostasis/metabolism

increased urine protein level ( J:113556 )

• about half of 8-month old mice have proteinuria in their urine at 30 mg/dl concentration

renal/urinary system

increased urine protein level ( J:113556 )

• about half of 8-month old mice have proteinuria in their urine at 30 mg/dl concentration

hematopoietic system

increased transitional stage B cell number ( J:113556 )

• numbers of T2 B cells are slightly enlarged in the spleen

decreased marginal zone B cell number ( J:113556 )

• marginal zone B cell numbers are reduced compared to controls

absent spleen marginal zone ( J:113556 )

• marginal zones could not be localized in these mice

abnormal B cell activation ( J:113556 )

• B cells have a strong response to T cell independent antigens producing higher levels of antigen-specific IgM, IgG2a, IgG2b class antibodies than wild-type controls

• however, there is no significant elevation of antigen-specific IgG1, IgG3, and IgA antibodies as is observed in transgenic mice on a wild-type background

• levels of antibodies produced are also lower than those in transgenic mice on a wild-type background