Phenotypes Associated with This Genotype

Genotype
MGI:3841106

• Allelic Composition: Cd40^tm1Kik/Cd40^tm1Kik; Tg(Tnfsf13b)1Fma/?
• Genetic Background: B6.Cg-Cd40^tm1Kik Tg(Tnfsf13b)1Fma

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal class switch recombination ( J:113556 )

• B cells exhibit reduced class switching in response to T cell-dependent antigens

increased marginal zone B cell number ( J:113556 )

• the number of splenic marginal zone B cells is increased by about 3-fold

absent spleen germinal center ( J:113556 )

• mice are defective in germinal center formation upon after immunization

abnormal B cell activation ( J:113556 )

• B cells have a vigorous response to T cell independent antigens producing much higher levels of antigen-specific IgG1, IgG2a, IgG2b, IgG3, and IgA class antibodies than controls

increased anti-double stranded DNA antibody level ( J:113556 )

• anti-dsDNA antibodies of the IgM class, IgA class, and all IgG subclasses are found in circulation

• titers of these auto-antibodies increase with age

glomerulonephritis ( J:113556 )

• kidneys of 10-month old mice have necrotic lesions

renal/urinary system

increased urine protein level ( J:113556 )

• all 8-month old mice have proteinuria in their urine at 100-300 mg/dl concentration

glomerulonephritis ( J:113556 )

• kidneys of 10-month old mice have necrotic lesions

renal glomerular immunoglobulin deposits ( J:113556 )

• immunohistology of kidneys with severe lesions reveal numerous glomerular deposits of IgG

homeostasis/metabolism

increased urine protein level ( J:113556 )

• all 8-month old mice have proteinuria in their urine at 100-300 mg/dl concentration

hematopoietic system

abnormal class switch recombination ( J:113556 )

• B cells exhibit reduced class switching in response to T cell-dependent antigens

increased marginal zone B cell number ( J:113556 )

• the number of splenic marginal zone B cells is increased by about 3-fold

absent spleen germinal center ( J:113556 )

• mice are defective in germinal center formation upon after immunization

abnormal B cell activation ( J:113556 )

• B cells have a vigorous response to T cell independent antigens producing much higher levels of antigen-specific IgG1, IgG2a, IgG2b, IgG3, and IgA class antibodies than controls