Phenotypes Associated with This Genotype

Genotype
MGI:3841045

• Allelic Composition: Pax2^1Neu/Pax2⁺; Wt1^tm1Jae/Wt1⁺
• Genetic Background: involves: 102 * 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:86661 )

• fewer than expected mice are observed at E16

postnatal lethality, incomplete penetrance ( J:86661 )

• 49% fewer than expected mice survive beyond weaning compared

renal/urinary system

increased kidney apoptosis ( J:86661 )

• at E16, whole kidney apoptosis is increased compared to in wild-type mice

abnormal kidney collecting duct morphology ( J:86661 )

• the volume of collecting ducts is reduced compared to in wild-type mice

decreased renal glomerulus number ( J:86661 )

• compared to in Pax2^1Neu heterozygotes and wild-type mice

abnormal kidney development ( J:86661 )

• at E16 and E19, mice exhibit abnormal kidney development that is more severe than in Pax2^1Neu heterozygotes

• however, kidney development at E13 is normal

kidney medulla hypoplasia ( J:86661 )

abnormal kidney calyx morphology ( J:86661 )

• renal calyces are reduced in size and number compared to in wild-type mice

small kidney ( J:86661 )

• the left kidney is 48% smaller than normal while the right kidney is 58% smaller than normal

decreased nephron number ( J:86661 )

• kidneys contain fewer than normal nephrons with fewer mesenchymal condensates, comma-shaped bodies, and S-shaped bodies and looser mesenchyme adjacent to ureteric bud structures compared to in wild-type kidneys

absent kidney ( J:86661 )

• in 20% of mice

cellular

increased kidney apoptosis ( J:86661 )

• at E16, whole kidney apoptosis is increased compared to in wild-type mice