Phenotypes Associated with This Genotype

Genotype
MGI:3840844

• Allelic Composition: Hoxd12^tm2Ddu/Hoxd12^tm2Ddu; Hoxd13^tm2Ddu/Hoxd13^tm2Ddu
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reduced male fertility ( J:47366 )

♂

limbs/digits/tail

abnormal carpal bone morphology ( J:47366 )

• d5 and d5* split from d4 and supernumerary distal carpal-like ossifications are found in the interdigital region unlike in wild-type mice

abnormal digit morphology ( J:47366 )

• digits are more severely affected than in Hoxd13^tm1Ddu

• malformed articulations in forelimb digits II, III, and IV form a single metacarpophalangeal rod unlike in wild-type mice

polydactyly ( J:47366 )

• in 20% of mice a broader than normal digit V splits to form a full postaxial extra digit

abnormal metatarsal bone morphology ( J:47366 )

• metatarsals V and I are broader than normal

skeleton

abnormal carpal bone morphology ( J:47366 )

• d5 and d5* split from d4 and supernumerary distal carpal-like ossifications are found in the interdigital region unlike in wild-type mice

abnormal metatarsal bone morphology ( J:47366 )

• metatarsals V and I are broader than normal