Phenotypes Associated with This Genotype

Genotype
MGI:3840643

• Allelic Composition: Abcb4^tm1Bor/Abcb4^tm1Bor; Tg(ABCG5/ABCG8)14-2Hobb/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:100491 )

N • plasma sitosterol and campesterol levels are normal

decreased intestinal cholesterol absorption ( J:100491 )

increased circulating alanine transaminase level ( J:100491 )

increased circulating aspartate transaminase level ( J:100491 )

liver/biliary system

abnormal bile composition ( J:100491 )

• bile cholesterol levels are decreased compared to in wild-type mice

digestive/alimentary system

abnormal feces composition ( J:100491 )

• fecal acidic sterol levels are decreased 30% compared to in wild-type mice

decreased intestinal cholesterol absorption ( J:100491 )

endocrine/exocrine glands

abnormal bile composition ( J:100491 )

• bile cholesterol levels are decreased compared to in wild-type mice