Mouse Genome Informatics
hm
    Kdm3atm1.1Yzha/Kdm3atm1.1Yzha
B6.129P2-Kdm3atm1.1Yzha
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
reproductive system

homeostasis/metabolism
N
• despite obesity, leptin, noreponephrin, epinephrin, testosterone, adiponectin, T3, and corticosterone serum levels are normal (J:147295)
• mice exhibit defective adaptive thermogenesis compared to wild-type mice

adipose tissue
• mice exhibit increased body fat compared to wild-type mice
• brown adipose tissue exhibits increased fat content compared to in wild-type mice
• beta-adrenergic-stimulated oxygen consumption and glycerol release in brown adipose tissue is reduced compared to in wild-type mice

growth/size/body

liver/biliary system

muscle
• large fat droplets are observed in muscles unlike in wild-type mice
• beta-oxidization in primary muscle is decreased compared to in wild-type mice
• glycerol release from the soleus muscle is decreased compared to in wild-type mice

behavior/neurological
N
• despite obesity, mice exhibit normal food intake regardless of diet fat content (J:147295)

Mouse Models of Human Disease
OMIM IDRef(s)
Obesity 601665 J:147295