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Phenotypes Associated with This Genotype
Genotype
MGI:3840234
Allelic
Composition
Kdm3atm1.1Yzha/Kdm3atm1.1Yzha
Genetic
Background
B6.129P2-Kdm3atm1.1Yzha
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm3atm1.1Yzha mutation (1 available); any Kdm3a mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
(J:147295)
(J:147295)

homeostasis/metabolism
N
• despite obesity, leptin, noreponephrin, epinephrin, testosterone, adiponectin, T3, and corticosterone serum levels are normal (J:147295)
• despite obesity, leptin, noreponephrin, epinephrin, testosterone, adiponectin, T3, and corticosterone serum levels are normal (J:147295)
• mice exhibit defective adaptive thermogenesis compared to wild-type mice (J:147295)
• mice exhibit defective adaptive thermogenesis compared to wild-type mice (J:147295)
• at night (J:147295)
• at night (J:147295)

adipose tissue
• mice exhibit increased body fat compared to wild-type mice (J:147295)
• mice exhibit increased body fat compared to wild-type mice (J:147295)
• brown adipose tissue exhibits increased fat content compared to in wild-type mice (J:147295)
• brown adipose tissue exhibits increased fat content compared to in wild-type mice (J:147295)
• beta-adrenergic-stimulated oxygen consumption and glycerol release in brown adipose tissue is reduced compared to in wild-type mice (J:147295)
• beta-adrenergic-stimulated oxygen consumption and glycerol release in brown adipose tissue is reduced compared to in wild-type mice (J:147295)

growth/size/body

liver/biliary system

muscle
• large fat droplets are observed in muscles unlike in wild-type mice (J:147295)
• large fat droplets are observed in muscles unlike in wild-type mice (J:147295)
• beta-oxidization in primary muscle is decreased compared to in wild-type mice (J:147295)
• glycerol release from the soleus muscle is decreased compared to in wild-type mice (J:147295)
• beta-oxidization in primary muscle is decreased compared to in wild-type mice (J:147295)
• glycerol release from the soleus muscle is decreased compared to in wild-type mice (J:147295)

behavior/neurological
N
• despite obesity, mice exhibit normal food intake regardless of diet fat content (J:147295)
• despite obesity, mice exhibit normal food intake regardless of diet fat content (J:147295)

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:147295


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory