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Phenotypes Associated with This Genotype
Genotype
MGI:3840234
Allelic
Composition
Kdm3atm1.1Yzha/Kdm3atm1.1Yzha
Genetic
Background
B6.129P2-Kdm3atm1.1Yzha
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm3atm1.1Yzha mutation (1 available); any Kdm3a mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system

homeostasis/metabolism
N
• despite obesity, leptin, noreponephrin, epinephrin, testosterone, adiponectin, T3, and corticosterone serum levels are normal
• mice exhibit defective adaptive thermogenesis compared to wild-type mice

adipose tissue
• brown adipose tissue exhibits increased fat content compared to in wild-type mice
• mice exhibit increased body fat compared to wild-type mice
• beta-adrenergic-stimulated oxygen consumption and glycerol release in brown adipose tissue is reduced compared to in wild-type mice

growth/size/body

liver/biliary system

muscle
• large fat droplets are observed in muscles unlike in wild-type mice
• beta-oxidization in primary muscle is decreased compared to in wild-type mice
• glycerol release from the soleus muscle is decreased compared to in wild-type mice

behavior/neurological
N
• despite obesity, mice exhibit normal food intake regardless of diet fat content

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:147295


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory