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Phenotypes Associated with This Genotype
Genotype
MGI:3839917
Allelic
Composition
Gt(ROSA)26Sortm2(GFP/tetX)Gld/Gt(ROSA)26Sor+
Sim1tm1.1(cre)Gld/Sim1+
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(GFP/tetX)Gld mutation (0 available); any Gt(ROSA)26Sor mutation (1060 available)
Sim1tm1.1(cre)Gld mutation (0 available); any Sim1 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• electroneurogram recordings from ventral roots indicates a suppression of synaptic transmission disrupting locomotor rhythm
• outputs from spinal cords show increased variability in the duration of individual motor bursts and in the length of the step cycle period which may be coupled with asymmetry in the duration of flexor bursts between the right and left sides of the spinal cord
• spinal cords show impaired production of locomotor like oscillations following induction with NMDA and 5-hydroxytryptamine or after electrical stimulation of sensory afferents


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/30/2025
MGI 6.24
The Jackson Laboratory