Phenotypes Associated with This Genotype

Genotype
MGI:3839781

• Allelic Composition: Tlr4^lps-del/Tlr4^lps-del
• Genetic Background: involves: C57BL/10ScN

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal tumor necrosis factor level ( J:114368 )

• diminished TNF alpha expression after 90 minutes of liver ischemia followed by 6 hours of reperfusion

decreased interleukin-10 secretion ( J:147023 )

• production is suppressed in response to E coli with or without adenosine

decreased interleukin-6 secretion ( J:147023 )

• production is suppressed in response to E coli

homeostasis/metabolism

abnormal circulating enzyme level ( J:114368 )

• myeloperoxidase levels are reduced after 90 minutes of liver ischemia followed by 6 hours of reperfusion

• increased HO-1 expression

decreased circulating alanine transaminase level ( J:114368 )

• serum levels decreased after 90 minutes of liver ischemia followed by 6 hours of reperfusion

abnormal tumor necrosis factor level ( J:114368 )

• diminished TNF alpha expression after 90 minutes of liver ischemia followed by 6 hours of reperfusion

nervous system

abnormal neuron differentiation ( J:129957 )

• improved differentiation of progenitor cells into neurons

• survival of newly formed neurons is reduced

brain ischemia ( J:148091 )

• improved neurological score relative to controls after ischemia/reperfusion

• reduced infarct size relative to controls at 24 hours after ischemia/reperfusion

cellular

abnormal neuron differentiation ( J:129957 )

• improved differentiation of progenitor cells into neurons

• survival of newly formed neurons is reduced