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Phenotypes Associated with This Genotype
Genotype
MGI:3839573
Allelic
Composition		 Plgtm1Dco/Plgtm1Dco
Tg(Alb-PLG)1Dgi/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plgtm1Dco mutation (0 available); any Plg mutation (7 available)
Tg(Alb-PLG)1Dgi mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:120780 )
N
• LPS-treated mice exhibit normal mortality

digestive/alimentary system
rectal prolapse ( J:120780 )
• mice exhibit a near complete rescue of the rectal prolapse observed in Plgtm1Dco homozygotes

growth/size/body
decreased body weight ( J:120780 )
• mice exhibit a near complete rescue of the decreased body weight observed in Plgtm1Dco homozygotes

liver/biliary system
liver/biliary system phenotype ( J:120780 )
N
• liver fibrosis observed in Plgtm1Dco homozygotes is reversed

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory