Phenotypes Associated with This Genotype

Genotype
MGI:3839572

• Allelic Composition: Plg^tm1Dco/Plg^tm1Dco
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:120780 )

• LPS-treated mice die unlike similarly treated wild-type mice

digestive/alimentary system

abnormal rectum morphology ( J:210802 )

• focal ulceration, inflammation, and fibrin deposition at the ano-rectal junction

rectal prolapse ( J:120780 )

growth/size/body

decreased body weight ( J:120780 )

liver/biliary system

liver fibrosis ( J:120780 , J:210802 )

• fibrin deposits and micrcalcifications (J:210802)

homeostasis/metabolism

increased circulating fibrinogen level ( J:210802 )

immune system

increased circulating fibrinogen level ( J:210802 )

enlarged lymph nodes ( J:210802 )

• proximal to the pancreas