Phenotypes Associated with This Genotype

Genotype
MGI:3839426

• Allelic Composition: Gabbr1^tm2Bet/Gabbr1^tm2Bet; Tg(HCRT-cre)1Stak/0
• Genetic Background: involves: BALB/cA * C57BL/6 * DBA/1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:146778 )

N • despite loss of Gabbr1 expression, no decrease in the number of orexin positive neurons is detected and spontaneous excitatory postsynaptic currents in orexin neurons are similar to controls

abnormal CNS synaptic transmission ( J:146778 )

• unlike in controls, treatment with bicuculline induces depolarization of orexin neurons

• membrane resistance of orexin neurons is significantly decreased

• glutamate and GABA-A agonists are less potent in inducing depolarizing currents in orexin neurons compared to controls

abnormal inhibitory postsynaptic currents ( J:146778 )

• increase in the frequency of fast spontaneous inhibitory postsynaptic currents in orexin neurons compared to control littermates

behavior/neurological

abnormal sleep pattern ( J:146778 )

• severe fragmentation of the sleep wake cycle with decreased awake, non-REM, and REM sleep episode durations and reduced REM latency

• fragmentation occurs in both the light and dark phases

• the delta power is significantly increased in non-REM sleep and the theta power is decreased during REM sleep compared to controls

• however, the overall amounts of wakefulness, non-REM and REM sleep are similar to controls