Phenotypes Associated with This Genotype

Genotype
MGI:3839233

• Allelic Composition: Rxra^tm1Ipc/Rxra^tm1Ipc; Rxrb^tm1Mma/Rxrb^tm1Mma
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal cornea stroma morphology ( J:146761 )

• the ventral portion is thickened at E14.5

ventral rotation of lens ( J:146761 )

• ventral rotation is seen at E14.5

abnormal eye development ( J:146761 )

• at E14.5 all mice have a persistent and hyperplasic primary vitreous body

abnormal eyelid morphology ( J:146761 )

• closer eyelid folds in mice at E14.5

abnormal ocular fundus morphology ( J:146761 )

optic disk coloboma ( J:146761 )

• small optic disc coloboma is seen in most mice at E14.5

abnormal retina morphology ( J:146761 )

• shortened ventral retina at E14.5

cardiovascular system

ventricular myocardium compact layer hypoplasia ( J:146761 )

• hypoplasia of the compact layer of the ventricular myocardium is seen in about 50% of mice

abnormal conotruncus septation ( J:146761 )

• agenesis of the conotruncal septum is occasionally seen at E14.5

nervous system

optic disk coloboma ( J:146761 )

• small optic disc coloboma is seen in most mice at E14.5

muscle

ventricular myocardium compact layer hypoplasia ( J:146761 )

• hypoplasia of the compact layer of the ventricular myocardium is seen in about 50% of mice