Phenotypes Associated with This Genotype

Genotype
MGI:3838802

• Allelic Composition: Ccm2^tm1.1Kwhi/Ccm2^tm1.1Kwhi
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:146527 )

• phenotype is stated to be identical to that of Ccm2 ^{Gt(RRG051)Byg} homozygotes; however no data are presented

cardiovascular system

abnormal cardiovascular system morphology ( J:146527 )

dilated dorsal aorta ( J:146527 )

aorta stenosis ( J:146527 )

decreased angiogenesis ( J:146527 )

abnormal vitelline vasculature morphology ( J:146527 )

poor circulation ( J:146527 )

craniofacial

abnormal pharyngeal arch morphology ( J:146527 )

abnormal first pharyngeal arch morphology ( J:146527 )

abnormal second pharyngeal arch morphology ( J:146527 )

abnormal third pharyngeal arch morphology ( J:146527 )

embryo

abnormal vitelline vasculature morphology ( J:146527 )

abnormal pharyngeal arch morphology ( J:146527 )

abnormal first pharyngeal arch morphology ( J:146527 )

abnormal second pharyngeal arch morphology ( J:146527 )

abnormal third pharyngeal arch morphology ( J:146527 )

abnormal vitelline vascular remodeling ( J:146527 )