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Phenotypes Associated with This Genotype
Genotype
MGI:3838616
Allelic
Composition		 Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Pdgfratm13Sor/Pdgfra+
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT)Nat mutation (3 available); any Gt(ROSA)26Sor mutation (1062 available)
Pdgfratm13Sor mutation (1 available); any Pdgfra mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
intestinal fibrosis ( J:146617 )
• 4 of 9 tamoxifen-treated mice exhibit intestinal fibrosis
intestine polyps ( J:146617 )
• in one tamoxifen-treated mouse

renal/urinary system
glomerulosclerosis ( J:146617 )
• sclerotic glomeruli in tamoxifen-treated mice
renal glomerulus hypertrophy ( J:146617 )
• enlarged glomeruli in tamoxifen-treated mice

cardiovascular system
cardiac fibrosis ( J:146617 )
• in tamoxifen-treated mice

muscle
skeletal muscle interstitial fibrosis ( J:146617 )
• in tamoxifen-treated mice

integument
tight skin ( J:146617 )
• in some tamoxifen-treated mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory