Phenotypes Associated with This Genotype

Genotype
MGI:3838398

• Allelic Composition: Chd2^{Gt(RRBO46)Byg}/Chd2^{Gt(RRBO46)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:146176 )

postnatal lethality, complete penetrance ( J:146743 )

• while mice are present in Mendelian ratios at E18.5, no mice are observed at weaning

cellular

abnormal cell cycle ( J:146176 )

• X-ray exposed mouse embryonic fibroblasts exhibit a moderately higher increase in G1-S phase compared to similarly treated wild-type cells

increased cellular sensitivity to methylmethanesulfonate ( J:146176 )

increased cellular sensitivity to X-ray irradiation ( J:146176 )

increased cellular sensitivity to ultraviolet irradiation ( J:146176 )

abnormal DNA repair ( J:146176 )

• 25% of mouse embryonic fibroblasts (MEFs) exhibit numerous DNA breaks unlike wild-type MEFs

• treatment of MEFs with X-ray causes more DNA damage than in similarly treated wild-type MEFs that persists for longer than in wild-type MEFs

hematopoietic system

abnormal blood cell morphology/development ( J:146176 )

• clusters of hematopoietic cells are less organized compared to in wild-type mice

abnormal erythropoiesis ( J:146176 )

• mice exhibit impaired erythropoiesis with decreased expression of CD71 and CD117 but not Ter119 in fetal liver cells compared to in wild-type mice

increased megakaryocyte cell number ( J:146176 )

• in neonate livers

decreased erythroid progenitor cell number ( J:146176 )

• in neonate livers

cardiovascular system

abnormal blood vessel morphology ( J:146176 )

• at E12.5

hemorrhage ( J:146176 )

• at E12.5

behavior/neurological

lethargy ( J:146176 )

• loss of vitality

growth/size/body

decreased fetal size ( J:146743 )

• at E18.5 but not E16.5

fetal growth retardation ( J:146743 )

• at E18.5, mice exhibit profound growth retardation compared to wild-type mice

homeostasis/metabolism

abnormal DNA repair ( J:146176 )

• 25% of mouse embryonic fibroblasts (MEFs) exhibit numerous DNA breaks unlike wild-type MEFs

• treatment of MEFs with X-ray causes more DNA damage than in similarly treated wild-type MEFs that persists for longer than in wild-type MEFs