Phenotypes Associated with This Genotype

Genotype
MGI:3837439

• Allelic Composition: Ptgs2^tm1Wlf/Ptgs2^tm1Wlf; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal chemical nociception ( J:146193 )

• mice treated with formalin exhibit a small decrease in the duration of pain behavior compared to similarly treated wild-type mice

• however, onset and peak of formalin induced pain is normal

abnormal nociception after inflammation ( J:146193 )

• mice fail to exhibit a decrease in the threshold of mechanical nociception following induction of inflammation unlike in similarly treated wild-type mice

• however, thermal nociception threshold following inflammation is normal

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:146193 )

N • LPS-treated mice develop fevers as in wild-type mice