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Phenotypes Associated with This Genotype
Genotype
MGI:3837308
Allelic
Composition		 Il6tm1Kopf/Il6tm1Kopf
Il6sttm1Ern/Il6sttm1Ern
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6sttm1Ern mutation (17 available); any Il6st mutation (85 available)
Il6tm1Kopf mutation (10 available); any Il6 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:139226 )
N
• neutrophil infiltration of the peritoneal cavity and subsequent clearance in induced inflammation normal
decreased susceptibility to endotoxin shock ( J:168781 )
• mice are resistant to LPS-induced shock

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory