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Phenotypes Associated with This Genotype
Genotype
MGI:3836995
Allelic
Composition
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp*D177N*M128V)A21Rchi/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Cwe mutation (29 available); any Prnp mutation (88 available)
Tg(Prnp*D177N*M128V)A21Rchi mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die from neurological disease with a mean lifespan of around 704 days
• the length of illness (mean day of onset until death) is around 293 days

behavior/neurological
• mice suffering form neurological disease tightly clasp hindlimbs upon lifting by tail
• mice develop ataxia with extension of hindlimbs and unbalanced posture with an age of onset around 452 days
• mice develop ataxia with extension of hindlimbs and unbalanced posture with an age of onset around 452 days

skeleton
• kyphosis occurs with the onset of ataxia

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Creutzfeldt-Jakob disease DOID:11949 OMIM:123400
J:142098


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/12/2019
MGI 6.13
The Jackson Laboratory