Phenotypes Associated with This Genotype

Genotype
MGI:3836578

• Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1⁺; Kras^tm1Bbd/Kras⁺; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:143034 )

• mice die prior to day 300

reproductive system

squamous metaplasia of bulbourethral gland ( J:143034 )

♂ • mice exhibit keratinized squamous metaplasia in the bulbourethral gland unlike wild-type mice

increased prostate gland tumor incidence ( J:143034 )

♂ • all mice develop diffuse, locally invasive carcinomas in the prostate that develop from solid or sheet-like proliferation with occasional rosette structures, nuclear atypia, apoptotic bodies, and mitosis unlike in wild-type mice

neoplasm

increased prostate gland tumor incidence ( J:143034 )

♂ • all mice develop diffuse, locally invasive carcinomas in the prostate that develop from solid or sheet-like proliferation with occasional rosette structures, nuclear atypia, apoptotic bodies, and mitosis unlike in wild-type mice

renal/urinary system

squamous metaplasia of urethral gland ( J:143034 )

• mice exhibit keratinized squamous metaplasia in the urethral gland unlike wild-type mice

endocrine/exocrine glands

squamous metaplasia of bulbourethral gland ( J:143034 )

♂ • mice exhibit keratinized squamous metaplasia in the bulbourethral gland unlike wild-type mice

increased prostate gland tumor incidence ( J:143034 )

♂ • all mice develop diffuse, locally invasive carcinomas in the prostate that develop from solid or sheet-like proliferation with occasional rosette structures, nuclear atypia, apoptotic bodies, and mitosis unlike in wild-type mice

squamous metaplasia of urethral gland ( J:143034 )

• mice exhibit keratinized squamous metaplasia in the urethral gland unlike wild-type mice